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Cardiovascular and Metabolic Health

By Atlantia Food Clinical Trials Ltd

Atlantia Food Clinical Trials has expertise in conducting trials in the related areas of cardiovascular health, metabolic health and obesity.

Atlantia Cardiovascular and Metabolic Health

Our researcher team will work with the client company to design a study most suitable for their products, analysing EFSA Guidelines 1, 2 and opinions, peer-reviewed publications, agreeing the most suitable end-points and statistically powering studies to ensure that studies will meet requirements. Some of the various clinical factors that we can evaluate include:

Cardiovascular Health

  • Lipid and lipoprotein profiles - total cholesterol, LDL cholesterol, HDL cholesterol, Apolipoprotein A1 and B, triglycerides, Omega 3 fatty acids EPA/DHA, Conjugated Linoleic acid
  • Inflammatory/cardiovascular markers - hsCRP, inflammatory cytokines, bradykinin, cortisol, ACE inhibition
  • Blood pressure - systolic/diastolic blood pressure, ambulatory blood pressure (e.g. 48hr)
  • Blood flow - endothelial function e.g. flow mediated dilation (FMD). We have an Ultrasonix machine and two sonographers highly trained in FMD. We work with imagelabonline in the Netherlands who specialise in image analysis.

Metabolic Health/Obesity

  • Body composition/body weight - lean muscle, % body fat, % body water etc. using DXA or Tanita anthropometric measurements - waist circumference, caliper skin fold thickness body composition analyser (bioimpedance)
  • Satiety related hormones - leptin, ghrelin, cholecystokinin plasma, GLP1, growth hormones
  • Metabolic markers, including post prandial blood glucose (e.g. 2hours), insulin, adiponectin, and glucagon
  • Behavioural assessments - appetite profile using visual analogue scales (VAS), reduced sense of hunger
  • Energy and nutrient intake
  • Weight management
  • Physical performance - exercise/daily activity log & questionnaires, strength/endurance testing
  • Quality of Life (QoL) questionnaires

1. Guidance on the scientific requirements for health claims related to appetite ratings, weight management and blood glucose concentration. EFSA J., 2012, 10(3): 2604
2. Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. EFSA J., 2011, 9 (12): 2474

Read Atlantia's Cardiovascular and Metabolic Health brochure for more information, or feel free to explore its dedicated site.